Overview
TB-500 is the synthetic, acetylated active fragment (17–23) of Thymosin Beta-4, represented by the sequence Ac-LKKTETQ. This research peptide is widely studied in laboratory and preclinical environments for its involvement in actin regulation, cellular migration, angiogenesis, tissue remodeling, and inflammatory pathway modulation.
Due to its defined active region and smaller molecular size, TB-500 is frequently utilized in in vitro and animal model systems investigating cytoskeletal dynamics, extracellular matrix organization, wound healing mechanisms, and vascular development. Researchers value TB-500 for its role in modeling regenerative signaling pathways and actin-mediated cellular processes.
At Pure Peptides, our TB-500 is supplied as a high-purity research compound intended strictly for laboratory use, with emphasis on quality, consistency, and research reliability.
Key Research Areas
(Summary of published preclinical findings – for informational and research-planning purposes only)
Actin-Binding & Cytoskeletal Research
TB-500 is extensively studied for its ability to interact with G-actin, influencing actin polymerization and cytoskeletal reorganization. In cell-based assays, this mechanism has been associated with enhanced cell migration and structural remodeling.
Angiogenesis & Vascular Formation Models
Preclinical wound and ischemia models suggest TB-500 may promote angiogenic signaling pathways, including increased VEGF expression and capillary density. These observations make it a frequent subject in vascular and regenerative biology research.
Musculoskeletal & Connective Tissue Studies
Animal studies involving tendon, ligament, and muscle injury models have reported improved collagen alignment, enhanced biomechanical strength, and accelerated structural repair when TB-500 was included in experimental protocols.
Inflammatory Pathway & Cytokine Modulation Research
In rodent inflammatory models, TB-500 has been observed to influence pro-inflammatory cytokines such as TNF-α and IL-6 while supporting resolution-phase tissue remodeling and minimizing fibrosis.
Cardiac & Neural Research Applications
Experimental myocardial infarction and nerve injury models have examined TB-500 for its potential role in oxidative stress reduction, cellular survival signaling, and structural tissue preservation.
Why Researchers Choose TB-500 from Pure Peptides
- High-purity TB-500 research peptide
- Batch-level quality verification
- Secure ordering and discreet U.S. shipping
- Dedicated customer support
- Reliable sourcing for laboratory research applications
Pure Peptides is committed to providing consistent, research-grade compounds for qualified laboratory use.
Chemical Information
TB-500 (Thymosin Beta-4 Fragment 17–23, Acetylated)
- Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-NH₂ (Ac-LKKTETQ)
- Molecular Formula: C₃₈H₆₈N₁₀O₁₄
- Molecular Weight: 889.01 g/mol
- Parent Protein CAS Number: 77591-33-4
- PubChem CID (Parent Protein): 16132341
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