Overview
Ipamorelin is a synthetic pentapeptide and highly selective growth hormone secretagogue (GHS) that acts as a potent agonist at the ghrelin receptor (GHS-R1a). It stimulates pulsatile growth hormone (GH) release from the pituitary with minimal effects on cortisol, prolactin, ACTH, or other pituitary hormones. It is widely used in laboratory and preclinical research as a model compound to investigate GH/IGF-1 axis regulation, anabolic signaling, lipolysis, and related metabolic pathways in various in vitro and animal model systems.
Research Applications (Observational Data from Published Studies) The following points summarize observations reported in scientific literature from preclinical (in vitro/animal) and human studies and are provided solely for informational and research-planning purposes:
- Growth Hormone Secretion Research: In rat, porcine, and healthy human volunteer studies, Ipamorelin produced dose-dependent, pulsatile GH release (up to 10–20-fold increases) with negligible impact on cortisol, prolactin, or ACTH levels.
- Muscle Growth and Recovery Models: In hypophysectomized rats and exercise/recovery rodent models, Ipamorelin increased lean body mass, enhanced protein synthesis, and accelerated muscle regeneration via elevated GH and IGF-1.
- Fat Metabolism Studies: In obese and diet-induced obesity rodent models, Ipamorelin significantly reduced visceral fat mass, increased lipolysis, and improved insulin sensitivity.
- Bone Density Research: In GH-deficient and ovariectomized rat models, Ipamorelin raised bone formation markers and improved trabecular bone density through GH-mediated mechanisms.
Important Legal Disclaimer For laboratory research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, cosmetic, or food purposes. Not approved by the FDA or any regulatory agency. Researchers are responsible for compliance with all applicable laws and institutional guidelines.
Chemical Information
- Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (amidated C-terminus)
- Common Name: Ipamorelin, NNC 26-0161, IPA
- Molecular Formula: C₃₈H₄₉N₉O₅
- Molecular Weight: 711.86 g/mol
- CAS Number: 170851-70-4
- PubChem CID: 9831659
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