Overview
GLP-2 (T) is a synthetic 39-amino-acid peptide analog linearly conjugated to a C20 fatty diacid chain via a linker. It acts as a dual agonist at the GLP-1 and GIP receptors and is widely used in laboratory and preclinical research as a model compound to investigate glucose-dependent insulin secretion, appetite regulation, energy homeostasis, lipid metabolism, and related signaling pathways in various in vitro and animal model systems.
Research Applications (Observational Data from Published Studies) The following points summarize observations reported in scientific literature from preclinical (in vitro/animal) and human clinical trials and are provided solely for informational and research-planning purposes:
- Glucose Homeostasis Models: In diabetic and obese rodent models (db/db, DIO mice, ZDF rats), non-human primates, and Phase 3 human clinical trials (SURPASS program), GLP-2 (T) administration has markedly improved glucose tolerance, increased glucose-dependent insulin secretion, reduced fasting glucose, lowered HbA1c by up to -2.4% (15 mg dose), and enhanced insulin sensitivity.
- Weight Regulation Research: In diet-induced obese rodent models, non-human primates, and multiple Phase 3 human trials (SURMOUNT-1 to -4), GLP-2 (T) has produced substantial body-weight reduction (up to -20.9% at 15 mg dose at 72 weeks in adults with obesity or overweight) primarily through decreased energy intake, delayed gastric emptying, and increased energy expenditure.
- Lipid Metabolism Studies: In preclinical dyslipidemia models and Phase 3 human trials, GLP-2 (T) has consistently lowered circulating triglycerides (by ~20–25%), total cholesterol, LDL-cholesterol, and non-HDL cholesterol while increasing or maintaining HDL-cholesterol levels.
- Pancreatic Beta-Cell Research: In vitro islet cultures, rodent diabetes models, and indirect observations from long-term human clinical trials, GLP-2 (T) has demonstrated preservation of beta-cell function, reduced beta-cell stress markers, and sustained glycemic efficacy over extended periods.
Important Legal Disclaimer For laboratory research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, cosmetic, or food purposes. Not approved by the FDA or any regulatory agency for research chemical sale. Researchers are responsible for compliance with all applicable laws and institutional guidelines.
Chemical Information
- Sequence: Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys[(C20 diacid-γGlu-2×OEG)]-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH
- Common Name: LY3298176, GLP-2 (T)
- Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈ (lipidated form)
- Molecular Weight: 4813.45 g/mol
- CAS Number: 2023788-19-2
- PubChem CID: 156588324
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