Overview
GHK-Cu + BPC-157 + TB-500 Blend combines three widely studied research peptides: the copper-tri-peptide GHK-Cu, the gastric pentadecapeptide derivative BPC-157, and the active fragment of Thymosin Beta-4 (TB-500, Ac-LKKTETQ). This blend is widely used in laboratory and preclinical research as a model system to investigate synergistic effects on tissue regeneration, angiogenesis, anti-inflammatory pathways, wound healing, and microvascular stability in various in vitro and animal model systems.
Research Applications (Observational Data from Published Studies) The following points summarize observations reported in scientific literature from preclinical (in vitro/animal) and human studies and are provided solely for informational and research-planning purposes:
- Wound Healing and Skin Regeneration: In rodent excisional wound and burn models, the combination accelerated re-epithelialization, increased collagen synthesis (GHK-Cu), enhanced keratinocyte/fibroblast migration (TB-500), and improved microvascular repair (BPC-157).
- Tissue Repair and Musculoskeletal Recovery: In rat tendon, ligament, and muscle injury models, co-administration promoted faster functional recovery, greater angiogenesis, reduced fibrosis, and superior tissue remodeling compared to individual peptides.
- Anti-Inflammatory and Vasoprotective Effects: Across multiple rodent inflammatory and ischemia-reperfusion models, the blend downregulated pro-inflammatory cytokines, stabilized endothelium, and minimized scar formation.
- Gastrointestinal and Systemic Protection: In rodent models of NSAID-induced damage and colitis, BPC-157 dominated gut protection while GHK-Cu and TB-500 contributed antioxidant and regenerative support.
Important Legal Disclaimer For laboratory research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, cosmetic, or food purposes. Not approved by the FDA or any regulatory agency. Researchers are responsible for compliance with all applicable laws and institutional guidelines.
Chemical Information
GHK-Cu Component
- Sequence: Gly-His-Lys-Cu²⁺ (copper complex)
- Molecular Formula: C₁₄H₂₂N₆O₄Cu (anhydrous)
- Molecular Weight: 401.94 g/mol
- CAS Number: 49557-75-7
- PubChem CID: 78173678
BPC-157 Component
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular Formula: C₆₂H₉₈N₁₆O₂₂
- Molecular Weight: 1419.54 g/mol
- CAS Number: 137525-51-0
- PubChem CID: 17757869
TB-500 Component (Thymosin Beta-4 Fragment 17–23, acetylated)
- Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-NH₂
- Molecular Formula: C₃₈H₆₈N₁₀O₁₄
- Molecular Weight: 889.01 g/mol
- CAS Number: 77591-33-4 (parent); fragment under research codes
- PubChem CID: 16132341
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