Overview
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated from the cerebral venous blood of sleep-deprived rabbits. It readily crosses the blood-brain barrier and is widely used in laboratory and preclinical research as a model compound to investigate delta-wave (slow-wave) sleep induction, stress-axis modulation, neuroprotection, circadian rhythm regulation, and related neurotransmitter pathways in various in vitro and animal model systems.
Research Applications (Observational Data from Published Studies) The following points summarize observations reported in scientific literature from preclinical (mostly rodent/rabbit) and early-phase human studies and are provided solely for informational and research-planning purposes:
- Sleep Architecture and Delta-Wave Promotion: In rabbit, rat, cat, and limited human EEG studies, intravenous or intracerebroventricular DSIP administration significantly increased total sleep time, prolonged slow-wave sleep (SWS) duration, increased delta-wave power, and reduced sleep latency without altering REM sleep proportion.
- Stress Response and Anxiolytic Models: In rodent elevated plus-maze, open-field, and restraint-stress models as well as small human trials, DSIP reduced behavioral signs of anxiety, lowered plasma cortisol/ACTH responses to stress, and normalized stress-induced alterations in catecholamine and serotonin turnover.
- Cognitive and Neuroprotective Effects Research: In rodent models of oxidative stress, excitotoxicity (kainic acid), and hypoxia, DSIP protected hippocampal neurons, reduced lipid peroxidation, normalized GABA/serotonin receptor binding, and improved memory consolidation during post-training sleep periods.
- Immune and Recovery Modulation Studies: In sleep-deprived rats and limited clinical observations, DSIP exhibited mild anti-inflammatory effects (reduced IL-6, TNF-α), enhanced antioxidant enzyme activity (SOD, catalase), and accelerated physiological recovery from physical/psychological stress.
Important Legal Disclaimer For laboratory research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, cosmetic, or food purposes. Not approved by the FDA or any regulatory agency. Researchers are responsible for compliance with all applicable laws and institutional guidelines.
Chemical Information
- Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
- Common Name: Delta Sleep-Inducing Peptide, DSIP, Emideltide
- Molecular Formula: C₃₅H₄₈N₁₀O₁₅
- Molecular Weight: 848.81 g/mol
- CAS Number: 62568-57-4
- PubChem CID: 119238
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