Overview
BPC-157 + TB-500 Blend is a research combination of two synthetic peptides: BPC-157 (a stable gastric pentadecapeptide) and TB-500 (the active N-terminal fragment Ac-LKKTETQ derived from Thymosin Beta-4). This blend is widely used in laboratory and preclinical research as a model system to investigate synergistic effects on angiogenesis, actin regulation, cell migration, tissue regeneration, anti-inflammatory pathways, and overall wound healing responses in various in vitro and animal model systems.
Research Applications (Observational Data from Published Studies) The following points summarize observations reported in scientific literature and are provided solely for informational and research-planning purposes:
- Tissue Repair and Musculoskeletal Recovery: In rat models of tendon/ligament transection, muscle crush injury, and Achilles tendon detachment, the combination of BPC-157 and TB-500 dramatically accelerated functional recovery, increased collagen deposition, improved biomechanical strength, and enhanced re-establishment of tissue architecture compared to either peptide alone.
- Angiogenesis and Wound Healing Models: In rodent excisional wound, burn, and ischemic flap models, co-administration promoted faster wound closure, greater vascularization (upregulated VEGF), increased keratinocyte and fibroblast migration (via TB-500’s actin-binding effects), and superior granulation tissue formation.
- Anti-Inflammatory and Cytokine Modulation Research: Across multiple rat inflammatory models (carrageenan-induced paw edema, colitis, arthritis), the blend synergistically reduced pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), inhibited leukocyte infiltration, and accelerated resolution of inflammation while minimizing fibrosis and scar formation.
- Neuroprotection and Systemic Protection Studies: In rat models of traumatic brain injury, spinal cord injury, and peripheral nerve damage, the combination improved motor function recovery, reduced oxidative stress, preserved neuronal integrity, and counteracted secondary damage more effectively than individual administration.
Important Legal Disclaimer For laboratory research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, cosmetic, or food purposes. Not approved by the FDA or any regulatory agency. Researchers are responsible for compliance with all applicable laws and institutional guidelines.
Chemical Information
BPC-157 Component
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular Formula: C₆₂H₉₈N₁₆O₂₂
- Molecular Weight: 1419.54 g/mol
- CAS Number: 137525-51-0
- PubChem CID: 17757869
TB-500 Component (Thymosin Beta-4 Fragment 17-23, acetylated)
- Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-NH₂ (Ac-LKKTETQ)
- Molecular Formula: C₃₈H₆₈N₁₀O₁₄
- Molecular Weight: 889.01 g/mol
- CAS Number: 77591-33-4 (parent Thymosin β4); fragment often listed under research codes
- PubChem CID: 16132341
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