{"product_id":"glp3-10mg","title":"GLP-3 (R) 10mg","description":"\u003cp dir=\"auto\"\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003eGLP-3 (R) is a synthetic 39-amino-acid peptide analog modified with a C20 fatty diacid chain. It acts as a triple agonist at the GLP-1, GIP, and glucagon receptors and is widely used in laboratory and preclinical research as a model compound to investigate energy balance, glucose homeostasis, lipid metabolism, and related signaling pathways in various in vitro and animal model systems.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eResearch Applications (Observational Data from Published Studies)\u003c\/strong\u003e The following points summarize observations reported in scientific literature from preclinical (in vitro\/animal) and human clinical trials and are provided solely for informational and research-planning purposes:\u003c\/p\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eWeight Regulation Research:\u003c\/strong\u003e In diet-induced obese rodent models, non-human primates, and Phase 2\/3 human clinical trials, GLP-3 (R) administration has produced profound body-weight reduction (up to -24.2% mean weight loss at 12 mg dose after 48 weeks in adults with obesity) primarily through decreased energy intake and markedly increased energy expenditure via glucagon receptor-mediated effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGlucose Homeostasis Models:\u003c\/strong\u003e In diabetic and obese animal models as well as Phase 2\/3 human trials in patients with type 2 diabetes, GLP-3 (R) has significantly improved glucose tolerance, lowered fasting glucose, reduced HbA1c by up to -2.02% (12 mg dose), and enhanced insulin sensitivity while suppressing hepatic glucose production.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLipid Metabolism Studies:\u003c\/strong\u003e In preclinical dyslipidemia models and human Phase 2 trials, GLP-3 (R) has consistently lowered circulating triglycerides (by ~30–50%), total cholesterol, LDL-cholesterol, and non-HDL cholesterol while favorably shifting overall lipid profiles.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver Fat Accumulation Research:\u003c\/strong\u003e In rodent models of MASLD\/NAFLD and a dedicated Phase 2 human substudy, GLP-3 (R) has markedly reduced hepatic steatosis and liver fat content (\u0026gt;80–85% relative reduction in MRI-PDFF at higher doses), together with improvements in liver inflammation and fibrosis markers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eImportant Legal Disclaimer\u003c\/strong\u003e For laboratory research use only. Not for human or veterinary use. Not for diagnostic, therapeutic, cosmetic, or food purposes. Not approved by the FDA or any regulatory agency. Researchers are responsible for compliance with all applicable laws and institutional guidelines.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eChemical Information\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Leu-Leu-Asp-Lys-Lys[(C20 diacid-γGlu-Aoc)]-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCommon Name:\u003c\/strong\u003e LY3437943, GLP-3 (R)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₂₂₃H₃₄₃N₄₇O₇₀ (approximate, lipidated form)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e ~4731–4845 g\/mol (commonly reported 4731.41 g\/mol)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2381089-83-2\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 171390338\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Pure Peptides","offers":[{"title":"Default Title","offer_id":50989176521009,"sku":"RT10","price":225.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0927\/1771\/1665\/files\/GLP-3_R.png?v=1773430404","url":"https:\/\/buypurepeptides.com\/products\/glp3-10mg","provider":"Pure Peptides","version":"1.0","type":"link"}